Pulmonary COVID is due to replicative protein, while in muscle COVID (vaccine), a predefined non replicative dose of COVID protein is administered. The initial immune response will be the same. Any vaccine when injected intramuscularly will cause a mild Th1 response but it may also cause an exaggerated Th1 and/or NLRP response.
Colchicine is TLR inflammasome inhibitor; it is IL-1 β, IL-18 and NF-kB inhibitor and therefore subdues the exaggerated immune response. If colchicine is added on the day of vaccination and continued for few days, the vaccine induced mild cytokine storm is not likely to occur.
Convert contraindication to indication to remove vaccine hesitancy.
Am I prone to get allergy?
Get tested with scratch test
Take H1 (levocetirizine 5mg) and H2 (ranitidine 150 mg/famotidine) blocker the day before the vaccine, on the day of vaccine and the day after
Take montelukast 10 mg the day before and on the day of vaccination.
Am I pro thrombo-inflammatory (CRP >1)?
Start colchicine a day before the vaccine, on the day of vaccine and continue till CRP is < 1.
Take mefenamic acid 500 mg on the day of vaccine.
The number of vaccinations in Singapore is 113000 with 432 adverse events and 3 anaphylaxis incidents that were treated in the clinic and not hospitalized.