This discussion is about the present expectation of and work going on to develop a Covid19 vaccine.
This first post will be frequently edited to include the present status of vaccine development as well as whether this vaccine will make any difference to the spread and response to Covid19 infection.. these views will be personal. In the subsequent posts are articles for reference on whatever is posted here. DO think about it for yourself.
Article 1 states: "As pharma firms scramble to find that big breakthrough, which could mean millions in profits and millions of lives saved, experts have warned that early vaccines may come with limitations on what they can do."
Article 5 states "Individuals who had been hospitalized for COVID-19 were more likely to have neutralizing antibodies than those who hadn't been hospitalized, suggesting that those with more severe illness are more likely to be immune in the future.
"There's another nugget of hope in this study. The researchers didn't stop by simply measuring how many people had neutralizing antibodies. They actually sequenced 89 different anti-COVID antibodies to determine which specific antibodies were highly neutralizing. They identified 52 that had neutralizing ability and several that had potent neutralizing ability, targeted to specific amino acids on the receptor binding domain.
And here's the thing: Most of the people in the study had those highly neutralizing antibodies; they just weren't the main antibodies they were producing. Why is this good news? Because it suggests a pathway for a successful vaccine. We can make these potent neutralizing antibodies; it's just that many of us don't. But a vaccine designed to promote that particular antibody response could be highly successful."
Article 7: Concludes: A vaccine does not expose the entirety of our immune system to the actual virus. These types of vaccines will only elicit antibodies that recognize the portion of the virus which is present in the vaccine. The other portions of the virus are not represented in the antibody pool. In this scenario, it is much more likely that the vaccine-induced antibodies can be rendered as non-neutralizing antibodies, because the entire virus is not coated in antibodies, only the portion that was used to develop the vaccine. In a real infection, our immune system is exposed to every nook and cranny of the entire virus, and as such, our immune system develops a panacea of antibodies that recognize different portions of the virus and, therefore, coat more of the virus and neutralize it. In addition, our immune system develops T-Cell responses to hundreds of different peptide epitopes across the virus; whereas in the vaccine the plethora of these T-Cell responses are absent.