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New Research 4: Potential Cure for ALS - Lou Gehrig’s Disease

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According to the study, in nearly all ALS patients, a protein called TDP-43 is responsible for forming abnormal clumps within cells, which causes cell death. In recent years, Strong’s team discovered a second protein, called RGNEF, with functions that are opposite to TDP-43.


The team’s research identified a specific fragment of the RGNEF protein -- named NF242 -- that can “mitigate the toxic effects of the ALS-causing protein.”


As a result, the researchers discovered that when the two proteins interact with each other, the toxicity of the ALS-causing protein is removed, which significantly reduces damage to the nerve cell and therefore prevents its death.



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